Academic Center for Obesity

Last updated: 365 days ago.

Patient care and research concerning: 1 Diagnostics of underlying causes of obesity (e.g. monogenetic/syndromal forms of obesity or a variety of other secondary causes, e.g. endocrine diseases or medication effects). 2 Personalized care for obesity for children and adults. 3 Prevention of overweight and obesity in the Netherlands.

Academic Center of Excellence

Research Activities

Research CGG Multidimensional:

  • Fundamental, e.g. immunological and endocrine mechanisms of weight reduction.
  • Translational, e.g. the role of stress hormones in obesity.
  • Clinical, e.g. development of a prediction model for personalized care, and studying novel treatments, role of movement behavior and fitness in obesity and weight reduction.
  • Epidemiological, e.g. collaborations with Generation R and Lifelines Cohort study. Activities:
  • Development of a prediction model to predict which patient (with his/her individual characteristics) will respond best to which type of treatment program using the CGG data-biobank. Multiple disciplines (see EMC collaborators) are contributing to the ongoing building of this data-biobank.

Ongoing collaborations with other top scientific institutes

  • The international Obesity Genetics Network (syndromal and monogenetic forms of obesity) e.g. Imperial College, London, UK and UMCU and VUMC Dept of Medical Genetics.
  • University of Maryland, Baltimore USA (endocrinology and weight loss).
  • VU University, Amsterdam,Dept of Health Sciences (prevention of childhood obesity).
  • University of Edinburgh, UK (role of stresshormones in obesity).
  • and multiple others

Type of

Collaborations

Ongoing collaborations with other top scientific institutes The international Obesity Genetics Network (syndromal and monogenetic forms of obesity) e.g. Imperial College, London, UK and UMCU and VUMC Dept of Medical Genetics. University of Maryland, Baltimore USA (endocrinology and weight loss). VU University, Amsterdam,Dept of Health Sciences (prevention of childhood obesity). University of Edinburgh, UK (role of stresshormones in obesity). and multiple others

e.g. Imperial College, London, UK and UMCU and VUMC Dept of Medical Genetics.

* University of Maryland, Baltimore USA (endocrinology and weight loss).

* VU University, Amsterdam,Dept of Health Sciences (prevention of childhood obesity).

* University of Edinburgh, UK (role of stresshormones in obesity).

* and multiple others

Educational

Contributions

Contribution of CGG to educational programs of Erasmus MC. General aim CGG: to educate students of medicine and psychology and a broad diversity of health care professionals how to improve the diagnostics of underlying causes of obesity and to learn how to adjust treatments to individual obese patients.

Insights in regulation of satiety, energy expenditure, body composition, novel developments in clinical, biological, epidemiological, psychosocial, (exercise) physiological, and behavioral factors contributing to obesity, as well as basic science aspects, are being taught. Providing yearly contribution to the EUR medicine Ba and MSc. PhD students are trained and supervised within the CGG in performing research in the field of obesity, as well as to providing patient care.

At postgraduate level, national trainings to experts in the multidisciplinary team, as well as to other health care professionals in the Netherlands is provided. Residents and clinical fellows are trained and supervised within the CGG in diagnostics of underlying causes of obesity, syndromal forms, and providing individualized patient care. Innovation of this education is a continuous process based on our own clinical/research findings, and novel knowledge from others worldwide. Lectures of CGG staff have reached high scores on participants' feedback (e.g. Noordwijkerhout course, Langerhans symposia).

Patient

Care Activities

By the appointment of best practice in the context of the project of Zorginstitute Netherlands and the Ministery of VWS "Care in 2030" (Zorg in 2030) the CGG has been appointed to be a role model and example for obesity care in the Netherlands. Care is provided in a multidisciplinary clinical pathway.

At least 80% of the care is labeled as academic according to the ROBIJN criteria/model. CGG uses the recently developed Value Based Health Care Outcome measures to improve patient care. In the future we also aim to compare the CGG to other (inter)national institutions involved in Obesity Care to further improve our patient care. Innovation: CGG is extending the number of (new) diagnoses in the field of syndromal and monogenetic obesity by using the newly developed Obesitome Chip (collaboration with the Dept of Clinical Genetics, UMCU) CGG is also optimizing care for obese patients with a physical disabilit, (focus of the department of Rehabilitiation Medicine).

CGG has an innovative eHealth program, which is delivered in combination with non-eHealth components of group-sessions and individual sessions (blended care). The current product will be upgraded, to reach optimal usage of the digital components: quantified self, gamification and social interaction.

Societal Relevance to Research, Education and Patient Care

Societal role: CGG fulfills multiple advisory roles at regional and international level: in the municipal of Rotterdam (Expertgroep Gezond Gewicht Rotterdam); and at a (inter)national level (Partnerschap Overgewicht Nederland- PON), the national project JOGG ("Jongeren op gezond gewicht"), and the European Medical and Strategic board. The CGG is also involved in preventive measures in the context of "Gezonder Rotterdam".

Policy: Although their active role in the PON, CGG staff will also contribute to (revision of) national obesity guidelines. In addition CGG had been asked as the major advisor with regard to obesity policies by NFU and by WRR (Wetenschappelijke Raad van de Regering). By the appointment of best practice in the context of the project of Zorginstitute Netherlands and the Ministery of VWS "Care in 2030" (Zorg in 2030) the CGG is been appointed to be a role model and example for obesity care in the Netherlands. We are currently working on implementing the different forms of combined lifestyle programs we developed in the CGG throughout the Netherlands, as the CGG is also recognized as leading the field of obesity treatments by the national Partnerschap Overgewicht Nederland.

Viability of Research, Education and Patient Care

By the appointment of best practice in the context of the project of Zorginstitute Netherlands and the Ministery of VWS "Care in 2030" (Zorg in 2030) the CGG is been appointed to be a role model and example for obesity care in the Netherlands. We are currently working on implementing the different forms of combined lifestyle programs we developed in the CGG throughout the Netherlands, as the CGG is also recognized as leading the field of obesity treatments by the national Partnerschap Overgewicht Nederland.

Recently, CGG PI's obtained major funding for obesity research (ZonMW Vidi, Thrasher Research Fund, US) and innovative patient care (Theia). Appointment of one of the CGG staff as member the board of the Dutch Endocrine Society (Ned Ver voor Endocrinologie), of Young Erasmus and of the Young Academy of the KNAW also contribute to extend opportunities to share our knowledge (inter)nationally. In addition, CGG PI's frequently present novel clinical and research findings at (inter)national congresses and national broadcasting.

Key and relevant publications of the last five years

  • Locke et al, Genetic studies of body mass index yield new insights for obesity biology. Nature. 2015 Feb12,518(7538):197-206. IF: 38.138, citations: 310
  • Shungin et al, New genetic loci link adipose and insulin biology to body fat distribution. Nature. 2015 Feb 12;518(7538):187-96. IF: 38.138, citations: 121
  • Manenschijn L, van Kruysbergen RG, de Jong FH, Koper JW, van Rossum EF. Shift work at young age is associated with elevated long-term cortisol levels and body mass index. J Clin Endocrinol Metab. 2011 Nov;96(11):E1862-5. .2011-1551. Q1, IF: 6.209 . Article has been awarded by the Dutch Society of Endocrinology (Nederlandse Vereniging voor Endocrinologie) for best publication in Endocrinology in 2011
  • Manenschijn L, Schaap L, van Schoor NM, van der Pas S, Peeters GM, Lips P, Koper JW, van Rossum EF. High long-term cortisol levels, measured in scalp hair, are associated with a history of cardiovascular disease. J Clin Endocrinol Metab.2013 May;98(5):2078-83. Q1, IF: 6.209. International press release by the Endocrine Society: cited e.g. in New York Times, and many other (inter)national newspapers and websites
  • EFC van Rossum & SWJ Lamberts. Polymorphisms in the Glucocorticoid Receptor Gene and their Associations with Metabolic Parameters and Body Composition. Recent Progress in Hormone Research, 2004;59:333-57. [Q1, IF: 9.263, cited: 162]
  • Noppe G, van den Akker EL, de Rijke YB, Koper JW, Jaddoe VW, van Rossum EF. Long-term glucocorticoid concentrations as a risk factor for childhood obesity and adverse body fat distribution.
  • Veldhorst MA, Noppe G, Jongejan MH, Kok CB, Mekic S, Koper JW, van Rossum EF,van den Akker EL. Increased scalp hair cortisol concentrations in obese children. J Clin Endocrinol Metab. 2014 Jan;99(1):285-90. doi: 10.1210/jc.2013-2924. Epub 2014 Jan 1. PubMed PMID: 24384019. Q1, IF: 6.209
  • Fani L, Bak S, Delhanty P, van Rossum EF, van den Akker EL. The melanocortin-4 receptor as target for obesity treatment: a systematic review of emerging pharmacological therapeutic options. Int J Obes (Lond). 2014 Feb;38(2):163-9. doi: 10.1038/ijo.2013.80. Epub 2013 Jun 18. Review. PubMed PMID:23774329. Q1, IF: 5.004
  • Manenschijn L, Koper JW, van den Akker EL, de Heide LJ, Geerdink EA, de Jong FH, Feelders RA, van Rossum EF. A novel tool in the diagnosis and follow-up of (cyclic) Cushing's syndrome: measurement of long-term cortisol in scalp hair. J Clin Endocrinol Metab. 2012 Oct;97(10):E1836-43. doi: 10.1210/jc.2012-1852. Epub 2012 Jul 27. Q1, IF: 6.209
  • Richardson L, Paulis WD, van Middelkoop M, Koes BW. An overview of national clinical guidelines for the management of childhood obesity in primary care. Prev Med. 2013 Nov;57(5):448-55.

PhD theses of the last five years

  • R. Kiewiet-Kemper. Medical and surgical use of the gut in the treatment of obesity. Promotor: A.J. van der Lelij; co-promoter: J.A.Visser, 2011
  • E.L.A.F. van Houten. The role of ovarian factors in the regulation of metabolism. Promotors: A.P.N. Themmen, J.S.E. Laven; co-promoter: J.A. Visser, 2014
  • L. Manenschijn Glucocorticoid exposure and sensitivity in Health and Disease, Promoter: Steven Lamberts.; co-promoter: EFC van Rossum 2013
  • Lucy Baldeon Rojas. Inflammatory aspects of type 2 diabetes in the Andean region. Erasmus MC, 7 oktober 2015, Rotterdam
  • Promoting a Healthy lifestyle. Effectiveness of an intervention on physical behaviour and physical tness among adolescents and young adults with spastic cerebral palsy. J. Slaman 2015
  • Baldéon Rojas. Inflammatory Aspects of Type 2 Diabetes in the Andean region. 2015
  • WD Paulis. Childhood Obesity in Primary Care. Not yet general practice. 2016.
  • J.C. van den Beukel. Regulation of Brown Adipose Tissue by Stress and Sex. Promotor: A.P.N. Themmen; co-promoter: A. Grefhorst, nov 2016
  • S. Staufenbiel. Relation of Long-term cortisol with obesity, depression and other stress-hormone related. 2016
  • G. Noppe. Long-term steroid Hormone concentrations in Healthy Children, in obesity and in disease. 2016

Non-scientific publications related to the ACE